Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.73 |
| ▸ | ACP1 | P24666 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063315 | 0.92 | RIPK1 (0.78) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL11215731 | 0.81 | RIPK1 (0.65) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL5212426 | 0.81 | RIPK1 (0.76) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL21642925 | 0.80 | ACP1 (0.74) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL1066924 | 0.79 | RIPK1 (0.66) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL11875528 | 0.79 | RIPK1 (0.62) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL11074177 | 0.78 | RIPK1 (0.55) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL5310554 | 0.76 | RIPK1 (0.73) | RIPK1ACP1MAPTALDH1A1KMT2A | |
| SCHEMBL22000881 | 0.76 | IDO1 (0.60) | RIPK1MAPTALDH1A1KMT2ADYRK1A | |
| SCHEMBL11211472 | 0.75 | ACP1 (0.53) | RIPK1ACP1MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021806-B1 | 2,3-DIHYDRO-IMIDAZO (2,1-B) BENZOTHIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-12 | — | — | EP | disclosed |
| US-4364942-A | ANTIDEPRESSANTS, INHIBITORS OF MONOAMINE OXIDASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-21 | — | — | US | disclosed |
| US-4340738-A | ENZYME INHIBITORS, ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-07-20 | — | — | US | disclosed |
| US-4262004-A | MONOAMINE OXIDASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-04-14 | — | — | US | disclosed |
| EP-0021806-A1 | 2,3-Dihydro-imidazo (2,1-b) benzothiazole derivatives and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-07 | — | — | EP | disclosed |