Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | ACP1 | P24666 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | NPY1R | P25929 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | STAT1 | P42224 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31730084 | 0.91 | RIPK1 (0.76) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL11204735 | 0.84 | RIPK1 (0.93) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL5005571 | 0.84 | RIPK1 (0.72) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL5212426 | 0.84 | RIPK1 (0.76) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL5005629 | 0.84 | RIPK1 (0.72) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL5001727 | 0.83 | RIPK1 (0.67) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL2116582 | 0.82 | DYRK1A (0.67) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL5213890 | 0.81 | RIPK1 (0.65) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL5215317 | 0.81 | BCHE (0.67) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 | |
| SCHEMBL14395001 | 0.81 | BCHE (0.67) | RIPK1DYRK1AKMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797054-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI Pharmaceuticals, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006017443-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | WO | disclosed |