Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 12/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1121676 | 0.85 | HTR3A (0.42) | HTR3AKCNH2CYP2C19PARP1AURKA | |
| SCHEMBL4155160 | 0.83 | RPS6KB1 (0.43) | HTR3AKCNH2CYP2C19PARP1AURKA | |
| SCHEMBL1121563 | 0.81 | RIPK1 (0.48) | HTR3AKCNH2CYP2C19PARP1AURKA | |
| SCHEMBL1121750 | 0.80 | PARP1 (0.47) | HTR3APARP1CHRM1 | |
| SCHEMBL1121260 | 0.78 | POLB (0.43) | HTR3A | |
| SCHEMBL1121610 | 0.78 | RPS6KB1 (0.41) | HTR3APARP1AURKARPS6KB1 | |
| SCHEMBL1121178 | 0.74 | SSTR5 (0.64) | KCNH2 | |
| SCHEMBL1121350 | 0.74 | IRAK4 (0.36) | AURKARPS6KB1 | |
| SCHEMBL1121250 | 0.73 | SSTR5 (0.65) | KCNH2 | |
| SCHEMBL1121464 | 0.72 | SSTR5 (0.57) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-B1 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-02-09 | — | — | EP | disclosed |