SCHEMBL11216233

SCHEMBL11216233

COC(=O)Cc1cc(N)c(O)c(Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.58
GAA P10253 3/20 0.58
GFER P55789 1/20 0.58
HSP90AB1 P08238 1/20 0.54
ACLY P53396 2/20 0.46
MEN1 O00255 1/20 0.43
ALOX15 P16050 1/20 0.43
HTT P42858 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CYP4F2 P78329 1/20 0.40
CYP4A11 Q02928 1/20 0.40
SLC7A5 Q01650 1/20 0.38
LMNA P02545 2/20 0.38
TSHR P16473 1/20 0.37
CA2 P00918 2/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA9 Q16790 1/20 0.37
NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5093783 0.88 ALDH1A1 (0.67) ALDH1A1GAAGFERHSP90AB1ACLY
SCHEMBL2926157 0.88 HSP90AB1 (0.63) ALDH1A1GAAGFERHSP90AB1ACLY
SCHEMBL11214618 0.84 GAA (0.44) ALDH1A1GAAGFERHSP90AB1ACLY
SCHEMBL11221411 0.84 ALDH1A1 (0.42) ALDH1A1GAAGFERHSP90AB1MEN1
SCHEMBL28118606 0.83 HSP90AB1 (0.58) ALDH1A1GAAGFERHSP90AB1ACLY
SCHEMBL14318546 0.83 HSP90AB1 (0.56) ALDH1A1GAAGFERHSP90AB1ACLY
SCHEMBL11225850 0.83 ALDH1A1 (0.60) ALDH1A1GAAGFERHSP90AB1ALOX15
SCHEMBL2927454 0.82 HSP90AB1 (0.56) ALDH1A1GAAGFERHSP90AB1ACLY
SCHEMBL7073645 0.81 HSP90AB1 (0.54) ALDH1A1GAAGFERHSP90AB1ACLY
SCHEMBL7637293 0.81 HSP90AB1 (0.54) ALDH1A1GAAGFERHSP90AB1ACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0081321-A1 2-Aminophenol derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1983-06-15 EP disclosed