SCHEMBL7637293

SCHEMBL7637293

COC(=O)Cc1cc(Cl)c(O)c(I)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 1/20 0.54
THRA P10827 2/20 0.44
THRB P10828 2/20 0.44
PPARG P37231 2/20 0.44
ITGB3 P05106 1/20 0.44
ITGAV P06756 1/20 0.44
RXRA P19793 1/20 0.44
ACLY P53396 1/20 0.43
ALDH1A1 P00352 2/20 0.43
GAA P10253 1/20 0.43
GFER P55789 1/20 0.43
CYP4F2 P78329 1/20 0.40
CYP4A11 Q02928 1/20 0.40
LMNA P02545 2/20 0.38
TSHR P16473 1/20 0.37
CA2 P00918 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
TRPV1 Q8NER1 3/20 0.36
SLC7A5 Q01650 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14485394 0.90 HSP90AB1 (0.66) HSP90AB1THRATHRBPPARGITGB3
SCHEMBL2926157 0.88 HSP90AB1 (0.63) HSP90AB1ACLYALDH1A1GAAGFER
SCHEMBL28118606 0.83 HSP90AB1 (0.58) HSP90AB1THRATHRBACLYALDH1A1
SCHEMBL2927454 0.82 HSP90AB1 (0.56) HSP90AB1ACLYALDH1A1GAAGFER
SCHEMBL28002484 0.81 HSP90AB1 (0.54) HSP90AB1ACLYALDH1A1GAAGFER
SCHEMBL11216233 0.81 ALDH1A1 (0.58) HSP90AB1ACLYALDH1A1GAAGFER
SCHEMBL7073645 0.81 HSP90AB1 (0.54) HSP90AB1THRATHRBPPARGACLY
SCHEMBL7643075 0.80 THRB (0.57) THRATHRBPPARGITGB3ITGAV
SCHEMBL1525946 0.78 THRB (0.73) HSP90AB1THRATHRBPPARGITGB3
SCHEMBL24132540 0.78 HSP90AB1 (0.58) HSP90AB1ACLYALDH1A1GAAGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021047556-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME AND USE THEREOF 上海长森药业有限公司 2021-03-18 WO disclosed
US-6465687-B1 SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE KARO BIO AB (SE) 2002-10-15 US disclosed
EP-1000008-A1 NOVEL THYROID RECEPTOR LIGANDS AND METHOD KARO BIO AB (SE) 2000-05-17 EP disclosed
WO-1999000353-A1 NOVEL THYROID RECEPTOR LIGANDS AND METHOD KARO BIO AB (SE) 1999-01-07 WO disclosed