SCHEMBL11216362

SCHEMBL11216362

Cc1ccc(C)c(C2C(=O)C3CCCC3C2=O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.46
NOS1 P29475 2/20 0.46
NOS2 P35228 2/20 0.46
ALDH1A1 P00352 3/20 0.38
HSD17B10 Q99714 2/20 0.38
KDM4E B2RXH2 2/20 0.38
KMT2A Q03164 2/20 0.38
CYP1A2 P05177 1/20 0.38
HPGD P15428 1/20 0.38
NPC1 O15118 1/20 0.38
MAPT P10636 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
GAA P10253 2/20 0.35
PBRM1 Q86U86 1/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34
DRD3 P35462 1/20 0.34
SRD5A1 P18405 2/20 0.33
DDB1 Q16531 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11216721 0.97 NOS3 (0.43) NOS3NOS1NOS2ALDH1A1HSD17B10
SCHEMBL11215620 0.83 NOS3 (0.43) NOS3NOS1NOS2ALDH1A1HSD17B10
SCHEMBL11219585 0.80 NOS1 (0.44) NOS3NOS1NOS2ALDH1A1KDM4E
SCHEMBL11214090 0.80 NOS3 (0.41) NOS3NOS1NOS2ALDH1A1KDM4E
SCHEMBL11215533 0.79 DDB1 (0.46) NOS3NOS1NOS2ALDH1A1HSD17B10
SCHEMBL10947809 0.75 DDB1 (0.46) NOS1ALDH1A1HSD17B10KDM4ENPC1
SCHEMBL1643853 0.74 NOS3 (0.44) NOS3NOS1NOS2ALDH1A1HSD17B10
SCHEMBL1643855 0.74 NOS3 (0.44) NOS3NOS1NOS2ALDH1A1HSD17B10
SCHEMBL11217842 0.72 HSD17B10 (0.38) NOS3NOS1NOS2ALDH1A1HSD17B10
SCHEMBL1617016 0.72 KMT2A (0.35) NOS3NOS1NOS2ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4338122-A MITICIDES, HERBICIDES UNION CARBIDE CORPORATION (US) 1982-07-06 US disclosed