SCHEMBL11216720

SCHEMBL11216720

NCCCC1NCCc2c1[nH]c1ccccc21

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GRIN2B Q13224 1/20 0.64
HTR7 P34969 8/20 0.56
CHRM4 P08173 5/20 0.55
CTSK P43235 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C19 P33261 1/20 0.55
DRD2 P14416 3/20 0.52
MAPKAPK2 P49137 1/20 0.51
HTR2A P28223 4/20 0.51
HTR2C P28335 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10857696 0.86 GRIN2B (0.67) GRIN2BHTR7CHRM4CTSKCYP3A4
SCHEMBL10851304 0.85 GRIN2B (0.66) GRIN2BHTR7CHRM4CTSKCYP3A4
SCHEMBL14892998 0.85 GRIN2B (0.62) GRIN2BHTR7CHRM4CTSKCYP3A4
Hydrochloric Acid SCHEMBL10851253 0.85 GRIN2B (0.66) GRIN2BHTR7CHRM4CTSKCYP3A4
Hydrochloric Acid SCHEMBL10854412 0.84 GRIN2B (0.64) GRIN2BHTR7CHRM4CTSKCYP3A4
SCHEMBL928865 0.81 GRIN2B (0.57) GRIN2BHTR7CHRM4CTSKCYP3A4
SCHEMBL18087743 0.81 GRIN2B (0.76) GRIN2BHTR7CHRM4CTSKCYP3A4
SCHEMBL5532807 0.80 GRIN2B (0.70) GRIN2BHTR7CHRM4CTSKCYP3A4
SCHEMBL21883968 0.80 GRIN2B (0.70) GRIN2BHTR7CHRM4CTSKCYP3A4
SCHEMBL8322968 0.80 GRIN2B (0.70) GRIN2BHTR7CHRM4CTSKCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-57028087-A None JP disclosed
JP-57028087-A None JP disclosed
JP-S5728087-A NOVEL 1-(3'-AMINOPROPYL)TETRAHYDRO-BETA-CARBOLINE COMPOUND AND ITS PREPARATION KAWAKEN FINE CHEM CO LTD 1982-02-15 JP disclosed
JP-S5728087-A NOVEL 1-(3'-AMINOPROPYL)TETRAHYDRO-BETA-CARBOLINE COMPOUND AND ITS PREPARATION KAWAKEN FINE CHEM CO LTD 1982-02-15 JP disclosed