Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 11/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 9/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.54 |
| ▸ | RAB9A | P51151 | 8/20 | 0.54 |
| ▸ | HTT | P42858 | 6/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27834211 | 0.81 | RIPK1 (0.63) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL21588479 | 0.81 | SMN1; SMN2 (0.50) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL21154015 | 0.81 | MAPT (0.60) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL21154204 | 0.81 | RAB9A (0.57) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL27864412 | 0.80 | MAPT (0.64) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL13932689 | 0.78 | RAB9A (0.57) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL17252042 | 0.78 | MAPT (0.70) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL13508874 | 0.77 | MAP3K5 (0.49) | ALDH1A1DYRK1ANPC1SMN1; SMN2RAB9A | |
| SCHEMBL11207220 | 0.76 | NPC1 (0.67) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL27834959 | 0.75 | DYRK1A (0.64) | MAPTKDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021806-B1 | 2,3-DIHYDRO-IMIDAZO (2,1-B) BENZOTHIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-12 | — | — | EP | disclosed |
| US-4364942-A | ANTIDEPRESSANTS, INHIBITORS OF MONOAMINE OXIDASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-21 | — | — | US | disclosed |
| US-4340738-A | ENZYME INHIBITORS, ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-07-20 | — | — | US | disclosed |
| US-4262004-A | MONOAMINE OXIDASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-04-14 | — | — | US | disclosed |