Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | RB1 | P06400 | 2/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048004 | 0.88 | NR2E1 (0.63) | SSTR3KCNH2NR2E1DRD2DRD1 | |
| SCHEMBL11204594 | 0.86 | NR2E1 (0.57) | SSTR3KCNH2NR2E1DRD2DRD1 | |
| SCHEMBL11199918 | 0.82 | PIM1 (0.49) | SSTR3KCNH2HTR2AHTR2CMAPT | |
| SCHEMBL31067106 | 0.73 | HCAR2 (0.40) | SSTR3KCNH2POLBMAPT | |
| SCHEMBL700531 | 0.73 | NR2E1 (1.00) | SSTR3KCNH2NR2E1RB1HTR2A | |
| SCHEMBL4288282 | 0.73 | NR2E1 (0.67) | SSTR3KCNH2NR2E1RB1HTR2A | |
| SCHEMBL21754250 | 0.73 | NR2E1 (0.67) | SSTR3KCNH2NR2E1RB1HTR2A | |
| SCHEMBL21900686 | 0.73 | NR2E1 (0.67) | SSTR3KCNH2NR2E1RB1HTR2A | |
| SCHEMBL29670383 | 0.73 | NR2E1 (1.00) | SSTR3KCNH2NR2E1RB1HTR2A | |
| SCHEMBL833503 | 0.73 | NR2E1 (1.00) | SSTR3KCNH2NR2E1RB1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |
| US-4292323-A | Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof | SCHERING CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |