Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10950638 | 0.77 | POLB (0.44) | POLBALOX15MGAMGAASI | |
| SCHEMBL5115722 | 0.77 | POLB (0.44) | POLBALOX15MGAMGAASI | |
| SCHEMBL25555608 | 0.77 | POLB (0.41) | POLBALOX15MGAMGAASI | |
| SCHEMBL8284379 | 0.77 | ALOX15 (0.39) | POLBALOX15MGAMGAASI | |
| SCHEMBL24189316 | 0.76 | POLB (0.43) | POLBALOX15MGAMGAASI | |
| SCHEMBL13639011 | 0.75 | MEN1 (0.37) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL6736700 | 0.75 | POLB (0.46) | POLBALOX15MGAMGAASI | |
| SCHEMBL27692286 | 0.74 | POLB (0.42) | POLBALOX15MGAMGAASI | |
| SCHEMBL17635968 | 0.74 | POLB (0.42) | POLBALOX15MGAMGAASI | |
| SCHEMBL372547 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068998-A1 | (Z)-1-aryl-2-aminomethyl-cyclopropane-carboxylates, their preparation and their use as medicines in the treatment of various disorders | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | disclosed |