SCHEMBL11218463

SCHEMBL11218463

COc1cccc2c1nc(C(=O)Cl)n2C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR3 P49682 1/20 0.46
TLR8 Q9NR97 1/20 0.42
NPSR1 Q6W5P4 1/20 0.40
PARP1 P09874 1/20 0.40
RAB9A P51151 1/20 0.39
PDE10A Q9Y233 2/20 0.39
NQO2 P16083 2/20 0.38
DYRK1A Q13627 1/20 0.38
ALDH1A1 P00352 3/20 0.38
MAPT P10636 2/20 0.38
MEN1 O00255 1/20 0.38
POLB P06746 1/20 0.38
ALOX15 P16050 1/20 0.38
RECQL P46063 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6953638 0.87 CXCR3 (0.56) CXCR3TLR8NPSR1PARP1RAB9A
SCHEMBL194252 0.78 TLR8 (0.48) TLR8RAB9APDE10ANQO2ALDH1A1
SCHEMBL6652836 0.74 NQO2 (0.49) TLR8RAB9APDE10ANQO2ALDH1A1
SCHEMBL7707554 0.74 TLR8 (0.48) TLR8RAB9APDE10ANQO2MAPT
SCHEMBL3860530 0.73 TLR8 (0.61) TLR8RAB9APDE10ANQO2ALDH1A1
SCHEMBL1161432 0.73 RAB9A (0.50) TLR8RAB9APDE10ANQO2ALDH1A1
SCHEMBL3534177 0.71 SMN1; SMN2 (0.56) RAB9AALDH1A1MAPTPOLBRECQL
SCHEMBL14685303 0.70 RAB9A (0.57) TLR8RAB9APDE10ANQO2MAPT
SCHEMBL6950074 0.70 TLR8 (0.44) TLR8NPSR1RAB9APDE10ANQO2
SCHEMBL14685298 0.69 PDE10A (0.53) TLR8NPSR1RAB9APDE10AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4326065-A PLASTICS, VARNISHES, POLYESTERS EASTMAN KODAK COMPANY (US) 1982-04-20 US disclosed
US-4251433-A BENZOTRIAZOLE DERIVATIVES; FOR POLYMERS EASTMAN KODAK COMPANY (US) 1981-02-17 US disclosed
US-4236013-A ADDITIVES FOR POLYMERS EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4137235-A ULTRAVIOLET STABILIZERS IN POLYMERIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1979-01-30 US disclosed
US-4116928-A Heterocylic ester, ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed