Sugi Predict

Sugi Predict / Compounds / SCHEMBL11220004

SCHEMBL11220004

SCHEMBL11220004

CCOC(=O)CS(=O)(=O)CC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 4/20 0.52
▸ MGAM O43451 1/20 0.52
▸ SI P14410 1/20 0.52
▸ MGAM2 Q2M2H8 1/20 0.52
▸ KMT2A Q03164 1/20 0.48
▸ ALDH1A1 P00352 4/20 0.48
▸ TRPA1 O75762 1/20 0.48
▸ LMNA P02545 2/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ ALOX15 P16050 1/20 0.40
▸ SOAT1 P35610 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.39
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA9 Q16790 1/20 0.38
▸ HSD11B1 P28845 1/20 0.37
▸ GSK3A P49840 1/20 0.36
▸ GSK3B P49841 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8413025 0.92 GAA (0.55) GAAMGAMSIMGAM2KMT2A
SCHEMBL10499223 0.84 GAA (0.46) GAAMGAMSIMGAM2KMT2A
SCHEMBL11226684 0.84 GAA (0.46) GAAMGAMSIMGAM2KMT2A
SCHEMBL11232767 0.82 GAA (0.44) GAAMGAMSIMGAM2KMT2A
SCHEMBL11232629 0.81 CYP1A2 (0.48) GAAMGAMSIMGAM2KMT2A
SCHEMBL11226349 0.81 GAA (0.43) GAAMGAMSIMGAM2KMT2A
SCHEMBL10498967 0.81 FAAH (0.44) GAAMGAMSIMGAM2KMT2A
SCHEMBL47545 0.80 GAA (0.52) GAAMGAMSIMGAM2KMT2A
SCHEMBL6181 0.80 GAA (0.52) GAAMGAMSIMGAM2KMT2A
SCHEMBL11361701 0.80 GAA (0.52) GAAMGAMSIMGAM2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250353820-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS NOVARTIS AG (CH) 2025-11-20 — — US disclosed
US-12466821-B2 Antiviral pyridopyrazinedione compounds NOVARTIS AG (CH) 2025-11-11 — — US disclosed
US-12338220-B2 Antiviral pyrazolopiridinone compounds GILEAD SCIENCES, INC. (US) 2025-06-24 — — US disclosed
US-20230365511-A1 Antiviral Pyrazolopiridinone Compounds NOVARTIS AG (CH) 2023-11-16 — — US disclosed
US-20230365511-A1 Antiviral Pyrazolopiridinone Compounds NOVARTIS AG (CH) 2023-11-16 — — US disclosed
US-11667613-B2 Antiviral pyrazolopyridinone compounds NOVARTIS AG (CH) 2023-06-06 — — US disclosed
US-11667613-B2 Antiviral pyrazolopyridinone compounds NOVARTIS AG (CH) 2023-06-06 — — US disclosed
US-20230052629-A1 ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2023-02-16 — — US disclosed
EP-4034537-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS Novartis AG (CH) 2022-08-03 — — EP disclosed
CN-114667285-A Antiviral pyrazolopyridinone compounds 诺华股份有限公司 2022-06-24 — — CN disclosed
WO-2021061898-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS NOVARTIS AG (CH) 2021-04-01 — — WO disclosed
WO-2020053654-A1 ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS NOVARTIS AG (CH) 2020-03-19 — — WO disclosed
US-20200079772-A1 ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS NOVARTIS AG (CH) 2020-03-12 — — US disclosed
WO-2015164573-A1 PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER VITAE PHARMACEUTICALS, INC. (US) 2015-10-29 — — WO disclosed
US-4326066-A Triazolyl coumarin compounds, processes for their preparation and their use as whiteners and laser dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1982-04-20 — — US disclosed
US-4155908-A PSORIASIS, ANTICOAGULANTS MERCK & CO., INC. (US) 1979-05-22 — — US disclosed
US-4128564-A 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins MERCK & CO., INC. (US) 1978-12-05 — — US disclosed
US-4085125-A 9-Thia-, 9-oxothia-, and 9-dioxothia-11,12-seco-prostaglandins and processes MERCK & CO., INC. (US) 1978-04-18 — — US disclosed
US-4066675-A PSORIASIS, THROMBOSIS MERCK & CO., INC. (US) 1978-01-03 — — US disclosed
US-4018802-A SKIN DISEASES, GROWTH HORMONE STIMULANTS, THROMBUS PREVENTION, IMMUNOLOGY MERCK & CO., INC. (US) 1977-04-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12466821-B2 Antiviral pyridopyrazinedione compounds ZC3HAV1, IL5, TYMP GAA 1363/4885MGAM 3858/4885SI 2806/4885
US-20230052629-A1 ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS ZC3HAV1, IL5, TYMP GAA 1363/4885MGAM 3858/4885SI 2806/4885
US-20250353820-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS ZC3HAV1, TYMP, ZC3HAV1L GAA 1233/4885MGAM 4015/4885SI 2655/4885
US-11667613-B2 Antiviral pyrazolopyridinone compounds ZC3HAV1, TYMP, ZC3HAV1L GAA 1233/4885MGAM 4015/4885SI 2655/4885
US-20230365511-A1 Antiviral Pyrazolopiridinone Compounds ZC3HAV1, ZC3HAV1L, RPL35 GAA 1777/4885MGAM 4340/4885SI 2746/4885
US-20200079772-A1 ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS ZC3HAV1, IL5, TYMP GAA 1363/4885MGAM 3858/4885SI 2806/4885
US-12338220-B2 Antiviral pyrazolopiridinone compounds ZC3HAV1, ZC3HAV1L, RPL35 GAA 1777/4885MGAM 4340/4885SI 2746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.