Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL6690175 | 1.00 | SMYD3 (0.38) | SMYD3CYP1A2ALOX15CYP2C19CYP2D6 | |
| Proline SCHEMBL28396348 | 1.00 | SMYD3 (0.38) | SMYD3CYP1A2ALOX15CYP2C19CYP2D6 | |
| Proline SCHEMBL1196248 | 0.91 | CYP1A2 (0.39) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL3226745 | 0.91 | CYP1A2 (0.39) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL4406680 | 0.91 | CYP1A2 (0.39) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL28898904 | 0.91 | CYP1A2 (0.39) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Threonine SCHEMBL6689277 | 0.91 | SMYD3 (0.36) | SMYD3CYP1A2ALOX15CYP2C19CYP2D6 | |
| Alanine SCHEMBL28248876 | 0.90 | SMYD3 (0.41) | SMYD3CYP1A2ALOX15CYP2C19CYP2D6 | |
| Proline SCHEMBL3100537 | 0.88 | NOS2 (0.37) | MEN1KMT2ADPP4DPP8DPP9 | |
| Proline SCHEMBL1702869 | 0.88 | NOS2 (0.37) | MEN1KMT2ADPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57165356-A | — | — | None | — | — | JP | disclosed |
| JP-S57165356-A | ACTIVE PEPTIDE | TOHO SHINYAKU KK | 1982-10-12 | — | — | JP | disclosed |