Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL4406680 | 1.00 | CYP1A2 (0.39) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL1196248 | 1.00 | CYP1A2 (0.39) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL28898904 | 1.00 | CYP1A2 (0.39) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL6690175 | 0.91 | SMYD3 (0.38) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL28396348 | 0.91 | SMYD3 (0.38) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL11221271 | 0.91 | SMYD3 (0.38) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL1642880 | 0.91 | CYP1A2 (0.46) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL14661418 | 0.91 | CYP1A2 (0.46) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Proline SCHEMBL6810009 | 0.91 | CYP1A2 (0.46) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| Glycine SCHEMBL1537355 | 0.87 | CYP2D6 (0.48) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021110834-A2 | COMPOUNDS AND METHODS FOR AMINE OXIDASE IMAGING | ETH ZURICH (CH) | 2021-06-10 | — | — | WO | claimed |
| EP-3831820-A1 | COMPOUNDS AND METHODS FOR AMINE OXIDASE IMAGING | ETH Zurich (CH) | 2021-06-09 | — | — | EP | claimed |
| US-20230104758-A1 | COMPOUNDS AND METHODS FOR AMINE OXIDASE IMAGING | ETH ZURICH (CH) | 2023-04-06 | — | — | US | disclosed |
| WO-2021110834-A2 | COMPOUNDS AND METHODS FOR AMINE OXIDASE IMAGING | ETH ZURICH (CH) | 2021-06-10 | — | — | WO | disclosed |
| EP-3831820-A1 | COMPOUNDS AND METHODS FOR AMINE OXIDASE IMAGING | ETH Zurich (CH) | 2021-06-09 | — | — | EP | disclosed |
| US-8541471-B2 | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2013-09-24 | — | — | US | disclosed |
| US-20100048697-A1 | WATER-SOLUBLE STRONTIUM SALTS FOR USE IN TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | HANSEN CHRISTIAN | 2010-02-25 | — | — | US | disclosed |
| US-7595342-B2 | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2009-09-29 | — | — | US | disclosed |
| US-20060122274-A1 | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230104758-A1 | COMPOUNDS AND METHODS FOR AMINE OXIDASE IMAGING | DAO, LOX, AOC2 | CYP1A2 179/4885ALOX15 434/4885CYP2C19 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.