Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9114061 | 0.80 | CYP2C19 (0.67) | CYP2C19SMN1; SMN2ALDH1A1KMT2AOPRD1 | |
| SCHEMBL8252373 | 0.74 | CYP2C19 (0.73) | CYP2C19SMN1; SMN2ALDH1A1MAPTKDM4E | |
| Methyl Alcohol SCHEMBL11775681 | 0.74 | CYP2C19 (0.93) | CYP2C19SMN1; SMN2HSD17B10 | |
| SCHEMBL9114406 | 0.73 | CYP2C19 (0.67) | CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL1458057 | 0.73 | CYP2C19 (1.00) | CYP2C19SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL666893 | 0.73 | CYP2C19 (1.00) | CYP2C19SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL5371218 | 0.73 | CYP2C19 (0.79) | CYP2C19SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL1458050 | 0.73 | CYP2C19 (1.00) | CYP2C19SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL23688606 | 0.72 | CYP2C19 (0.65) | CYP2C19SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL8669701 | 0.72 | CYP2C19 (0.65) | CYP2C19SMN1; SMN2MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4399146-A | Treatment of atherosclerosis with khellin-related furochromones | THE UPJOHN COMPANY (US) | 1983-08-16 | — | — | US | disclosed |
| US-4313881-A | 5-Hydroxyfurochromones | THE UPJOHN COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4313883-A | ANTHIATHEROSCLEROSIS | THE UPJOHN COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4313882-A | 7-Methyl-6-methylthio-, methylsulfinyl-, and methylsulfonyl-methyl-furochromones | THE UPJOHN COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4304722-A | Benzo[1,2-b:5,4-b']difuran-3(2H)-ones | THE UPJOHN COMPANY (US) | 1981-12-08 | — | — | US | disclosed |
| US-4284569-A | Antiatherosclerotic furochromones | THE UPJOHN COMPANY (US) | 1981-08-18 | — | — | US | disclosed |
| US-4281013-A | Antiatherosclerotic use of khellin and khellinin | THE UPJOHN COMPANY (US) | 1981-07-28 | — | — | US | disclosed |