SCHEMBL11222733

SCHEMBL11222733

FC(F)(F)c1ccc(Oc2ccc(CCl)cc2)c(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 5/20 0.66
HTR2A P28223 5/20 0.50
SLC6A4 P31645 5/20 0.50
KCNH2 Q12809 5/20 0.50
TTR P02766 2/20 0.48
MEN1 O00255 1/20 0.48
PPOX P50336 1/20 0.48
KMT2A Q03164 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
MRGPRX4 Q96LA9 4/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
ATM Q13315 1/20 0.46
RAB9A P51151 1/20 0.46
PPARD Q03181 1/20 0.44
PPARA Q07869 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11095176 0.89 FFAR1 (0.65) FFAR1HTR2ASLC6A4KCNH2TTR
SCHEMBL12967470 0.87 FFAR1 (0.64) FFAR1HTR2ASLC6A4KCNH2TTR
SCHEMBL921043 0.87 FFAR1 (0.64) FFAR1HTR2ASLC6A4KCNH2TTR
SCHEMBL10693814 0.84 MRGPRX4 (0.52) FFAR1HTR2ASLC6A4KCNH2TTR
SCHEMBL17042865 0.84 FFAR1 (0.69) FFAR1HTR2ASLC6A4KCNH2TTR
SCHEMBL10969104 0.84 FFAR1 (0.60) FFAR1HTR2ASLC6A4KCNH2TTR
SCHEMBL11229522 0.83 FFAR1 (0.60) FFAR1HTR2ASLC6A4KCNH2TTR
Hydrochloric Acid SCHEMBL17042503 0.83 FFAR1 (0.67) FFAR1TTRMEN1PPOXKMT2A
SCHEMBL10482071 0.82 HTR2A (0.54) FFAR1HTR2ASLC6A4KCNH2TTR
SCHEMBL15684989 0.82 FFAR1 (0.66) FFAR1HTR2ASLC6A4KCNH2TTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4353736-A CROPS OF BARLEY, WHEAT, CORN, RICE OR COATS CIBA-GEIGY CORPORATION (US) 1982-10-12 US disclosed