Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122276 | 0.79 | MAPT (0.49) | MAPTSMN1; SMN2TP53THRBTSHR | |
| SCHEMBL1121993 | 0.77 | NOS1 (0.42) | MAPT | |
| SCHEMBL9037372 | 0.70 | NPC1 (0.51) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL1121995 | 0.66 | NOS1 (0.69) | — | |
| SCHEMBL9039064 | 0.66 | NPC1 (0.41) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL6961637 | 0.66 | POLB (0.44) | MAPTSMN1; SMN2TP53ALDH1A1HPGD | |
| SCHEMBL6958210 | 0.65 | GAA (0.49) | MAPTSMN1; SMN2TP53ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL9280168 | 0.65 | NPC1 (0.41) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL6963560 | 0.65 | GAA (0.49) | MAPTSMN1; SMN2TP53ALDH1A1GAA | |
| SCHEMBL9219873 | 0.65 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883451-B9 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2011-02-09 | — | — | EP | claimed |
| EP-1883451-B1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2010-11-24 | — | — | EP | claimed |