Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | NOS3 | P29474 | 4/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122274 | 0.79 | MAPT (0.51) | MAPTTSHRTP53SMN1; SMN2THRB | |
| SCHEMBL1121995 | 0.76 | NOS1 (0.69) | NOS3NOS1NOS2 | |
| SCHEMBL9037376 | 0.71 | NOS1 (0.78) | NOS3NOS1NOS2 | |
| SCHEMBL9039073 | 0.67 | NOS1 (0.71) | NOS3NOS1NOS2 | |
| SCHEMBL6961641 | 0.66 | NOS1 (0.64) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL9280170 | 0.66 | NOS1 (0.70) | NOS3NOS1NOS2 | |
| Bromide SCHEMBL6962474 | 0.66 | NOS1 (0.70) | NOS3NOS1NOS2 | |
| SCHEMBL9037979 | 0.66 | NOS1 (0.78) | NOS3NOS1NOS2 | |
| SCHEMBL6963562 | 0.66 | NOS1 (0.78) | NOS3NOS1NOS2 | |
| SCHEMBL9219878 | 0.66 | NOS3 (0.73) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883451-B9 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2011-02-09 | — | — | EP | claimed |
| EP-1883451-B1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2010-11-24 | — | — | EP | claimed |