Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | UQCRB | P14927 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | GFER | P55789 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL831034 | 0.84 | HPGD (0.51) | CA2CA1HPGDLMNAALDH1A1 | |
| SCHEMBL830095 | 0.83 | CA1 (0.50) | CA2CA1HPGDLMNAGAA | |
| SCHEMBL6665659 | 0.83 | CA1 (0.50) | CA2CA1HPGDLMNAALOX15 | |
| SCHEMBL2557584 | 0.80 | HPGD (0.65) | CA2CA1HPGDLMNAALDH1A1 | |
| SCHEMBL1122574 | 0.80 | CA1 (0.56) | CA2CA1CA12CA4CA7 | |
| SCHEMBL15904304 | 0.79 | HPGD (0.41) | CA2CA1HPGDLMNAALDH1A1 | |
| SCHEMBL829810 | 0.79 | CA1 (0.54) | CA2CA1HPGDLMNAALDH1A1 | |
| SCHEMBL6295481 | 0.78 | HPGD (0.64) | CA2CA1HPGDLMNAUQCRB | |
| SCHEMBL18047835 | 0.76 | CA1 (0.55) | CA2CA1CYP1A1HPGDLMNA | |
| SCHEMBL11504884 | 0.74 | KMT2A (0.56) | CA2CA1HPGDLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |