Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 19/20 | 0.56 |
| ▸ | CA2 | P00918 | 19/20 | 0.56 |
| ▸ | CA12 | O43570 | 9/20 | 0.56 |
| ▸ | CA9 | Q16790 | 9/20 | 0.56 |
| ▸ | CA4 | P22748 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122298 | 0.80 | CA2 (0.52) | CA1CA2CA12CA9CA4 | |
| SCHEMBL831034 | 0.80 | HPGD (0.51) | CA1CA2CA12CA9CA4 | |
| SCHEMBL830095 | 0.79 | CA1 (0.50) | CA1CA2CA12CA9CA4 | |
| SCHEMBL6665659 | 0.79 | CA1 (0.50) | CA1CA2CA12CA9KMT2A | |
| SCHEMBL2557584 | 0.76 | HPGD (0.65) | CA1CA2CA12CA9KMT2A | |
| SCHEMBL8637752 | 0.75 | CA1 (0.68) | CA1CA2CA12CA9CA4 | |
| SCHEMBL15904304 | 0.75 | HPGD (0.41) | CA1CA2KMT2A | |
| SCHEMBL829810 | 0.75 | CA1 (0.54) | CA1CA2CA12CA9CA4 | |
| SCHEMBL28472964 | 0.73 | CA2 (1.00) | CA1CA2CA12CA9CA4 | |
| SCHEMBL27536397 | 0.72 | CA1 (0.70) | CA1CA2CA12CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |