Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 9/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11225814 | 0.86 | CCNC (0.34) | GSK3BCCNCCDK8CCNT1CCNA2 | |
| SCHEMBL11236377 | 0.84 | GSK3B (0.48) | GSK3BMAPK1PIK3CA | |
| SCHEMBL11235458 | 0.82 | GSK3B (0.55) | GSK3BCCNCCDK8MAP4K1CCNT1 | |
| SCHEMBL11381325 | 0.80 | CCNC (0.40) | CCNCCDK8MAP4K1CCNT1CCNA2 | |
| SCHEMBL11230162 | 0.74 | GSK3B (0.46) | GSK3BMAPK1 | |
| SCHEMBL11127750 | 0.72 | CCNC (0.43) | GSK3BCCNCCDK8MAPK1 | |
| SCHEMBL11229632 | 0.72 | GSK3B (0.52) | GSK3BCDK2MAPK1 | |
| SCHEMBL11234436 | 0.70 | GSK3B (0.50) | GSK3BCDK2MAPK1PIK3CA | |
| SCHEMBL11229063 | 0.70 | CCNC (0.36) | CCNCCDK8 | |
| SCHEMBL11244896 | 0.69 | GSK3B (0.49) | GSK3BMAPK1AKT1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |