Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229725 | 0.77 | NR1D1 (0.37) | GRIN1GRIN2BKDM4C | |
| SCHEMBL11225814 | 0.76 | CCNC (0.34) | CCNCCDK8KDM4C | |
| SCHEMBL11231822 | 0.70 | GSK3A (0.37) | KDM4C | |
| SCHEMBL11223356 | 0.70 | GSK3B (0.37) | CCNCCDK8 | |
| SCHEMBL11127750 | 0.67 | CCNC (0.43) | CCNCCDK8GRIN1GRIN2B | |
| SCHEMBL11235458 | 0.66 | GSK3B (0.55) | CCNCCDK8KDM4C | |
| SCHEMBL11236571 | 0.66 | NR1D1 (0.33) | — | |
| SCHEMBL11229058 | 0.65 | LATS1 (0.39) | CCNCCDK8KDM4C | |
| SCHEMBL11243742 | 0.65 | KDM4E (0.47) | CCNCCDK8 | |
| SCHEMBL11228877 | 0.65 | GSK3B (0.45) | KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |