Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | PEPD | P12955 | 5/20 | 0.36 |
| ▸ | XPNPEP1 | Q9NQW7 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27970159 | 0.86 | ACE (0.46) | ACENPSR1HSD17B10DPP4DPP8 | |
| SCHEMBL11342331 | 0.81 | HSD17B10 (0.51) | ACENPSR1HSD17B10MMP2ANPEP | |
| SCHEMBL9109446 | 0.80 | NPSR1 (0.50) | ACENPSR1HSD17B10DPP4DPP8 | |
| SCHEMBL11155540 | 0.79 | ACE (0.49) | ACENPSR1HSD17B10DPP4DPP8 | |
| SCHEMBL11164632 | 0.78 | ACE (0.48) | ACENPSR1HSD17B10DPP4DPP8 | |
| SCHEMBL11355229 | 0.78 | ACE (0.48) | ACENPSR1HSD17B10 | |
| SCHEMBL200924 | 0.76 | RAB9A (0.46) | ACENPSR1HSD17B10DPP4DPP8 | |
| SCHEMBL27970157 | 0.74 | NPSR1 (0.46) | ACENPSR1HSD17B10DPP4DPP8 | |
| SCHEMBL27970090 | 0.73 | HSD17B10 (0.45) | ACENPSR1HSD17B10DPP4DPP8 | |
| SCHEMBL200923 | 0.73 | ATM (0.46) | NPSR1HSD17B10DPP4DPP8DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316896-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0009183-B1 | PHOSPHORYL AMINOACID DERIVATIVES AND COMPOSITION FOR TREATING HYPERTENSION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1981-10-21 | — | — | EP | disclosed |
| EP-0009183-A1 | Phosphoryl aminoacid derivatives and composition for treating hypertension containing the same | MERCK & CO. INC. (US) | 1980-04-02 | — | — | EP | disclosed |