Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122421 | 1.00 | VCP (0.39) | VCPCA12CA1CA2CA7 | |
| SCHEMBL1323346 | 0.74 | CA1 (0.42) | VCPCA12CA1CA2CA7 | |
| SCHEMBL2306678 | 0.74 | VCP (0.39) | VCPCA12CA1CA2CA7 | |
| SCHEMBL1323345 | 0.74 | CA1 (0.42) | VCPCA12CA1CA2CA7 | |
| SCHEMBL1324203 | 0.72 | VCP (0.38) | VCPCA1CA2 | |
| SCHEMBL1324942 | 0.72 | VCP (0.38) | VCPCA1CA2 | |
| SCHEMBL13011988 | 0.72 | NFE2L2 (0.47) | — | |
| SCHEMBL8594457 | 0.69 | VCP (0.48) | VCPCA12CA1CA2CA7 | |
| SCHEMBL13790239 | 0.69 | VCP (0.48) | VCPCA12CA1CA2CA7 | |
| SCHEMBL13790319 | 0.69 | VCP (0.48) | VCPCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |
| US-6646009-B2 | Use against proliferative disorders including cancer, and as a radioprotective compound for normal cells from ionizing radiation | Temple University — Of Commonwealth System of Higher Education | 2003-11-11 | — | — | US | disclosed |