Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.51 |
| ▸ | ITK | Q08881 | 5/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11224250 | 1.00 | PDE3B (0.51) | PDE3BPDE3AITKCDC7CDK5 | |
| SCHEMBL11231364 | 0.91 | PDE3B (0.53) | PDE3BPDE3AITKCDK5CDK5R1 | |
| SCHEMBL11231359 | 0.91 | PDE3B (0.53) | PDE3BPDE3AITKCDK5CDK5R1 | |
| SCHEMBL11227734 | 0.88 | PDE3B (0.38) | PDE3BPDE3AGAAMAPTKDM4E | |
| SCHEMBL11227737 | 0.88 | PDE3B (0.38) | PDE3BPDE3AGAAMAPTKDM4E | |
| SCHEMBL11229983 | 0.87 | PDE3B (0.38) | PDE3BPDE3ACDK5CDK5R1GAA | |
| SCHEMBL11229981 | 0.87 | PDE3B (0.38) | PDE3BPDE3ACDK5CDK5R1GAA | |
| SCHEMBL11234122 | 0.87 | PDE3B (0.56) | PDE3BPDE3AITKCDC7CDK5 | |
| SCHEMBL11232562 | 0.85 | PDE3B (0.51) | PDE3BPDE3AITKCDC7GAA | |
| SCHEMBL11232554 | 0.85 | PDE3B (0.51) | PDE3BPDE3AITKCDC7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |