Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227737 | 1.00 | PDE3B (0.38) | PDE3BPDE3AABL1MAPTKDM4E | |
| SCHEMBL11224250 | 0.88 | PDE3B (0.51) | PDE3BPDE3AMAPTKDM4EGAA | |
| SCHEMBL11224253 | 0.88 | PDE3B (0.51) | PDE3BPDE3AMAPTKDM4EGAA | |
| SCHEMBL11235927 | 0.84 | NPC1 (0.44) | PDE3BPDE3AABL1MAPTKDM4E | |
| SCHEMBL11231407 | 0.83 | PDE3B (0.41) | PDE3BPDE3AABL1ALDH1A1HPGD | |
| SCHEMBL11231386 | 0.83 | PDE3B (0.41) | PDE3BPDE3AABL1ALDH1A1HPGD | |
| SCHEMBL11229981 | 0.82 | PDE3B (0.38) | PDE3BPDE3AABL1MAPTKDM4E | |
| SCHEMBL11229983 | 0.82 | PDE3B (0.38) | PDE3BPDE3AABL1MAPTKDM4E | |
| SCHEMBL11230309 | 0.81 | MKNK1 (0.49) | PDE3BPDE3AABL1KDM4EKMT2A | |
| SCHEMBL11231364 | 0.80 | PDE3B (0.53) | PDE3BPDE3AMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |