Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | WNT3A | P56704 | 2/20 | 0.33 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229983 | 1.00 | PDE3B (0.38) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11224253 | 0.87 | PDE3B (0.51) | PDE3BPDE3ACCNCCDK8KDM4E | |
| SCHEMBL11224250 | 0.87 | PDE3B (0.51) | PDE3BPDE3ACCNCCDK8KDM4E | |
| SCHEMBL11224968 | 0.83 | PDE3B (0.40) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11224972 | 0.83 | PDE3B (0.40) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11227737 | 0.82 | PDE3B (0.38) | PDE3BPDE3AABL1KDM4EGAA | |
| SCHEMBL11227734 | 0.82 | PDE3B (0.38) | PDE3BPDE3AABL1KDM4EGAA | |
| SCHEMBL11240170 | 0.80 | GPR142 (0.36) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11231359 | 0.79 | PDE3B (0.53) | PDE3BPDE3AKDM4EGAAMAPT | |
| SCHEMBL11231364 | 0.79 | PDE3B (0.53) | PDE3BPDE3AKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |