Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 9/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11221980 | 0.85 | ACE (0.47) | ACEL3MBTL1CHRM2CHRM4CHRM1 | |
| SCHEMBL6290811 | 0.83 | L3MBTL1 (0.57) | MMP8MMP12MMP13L3MBTL1ALDH1A1 | |
| SCHEMBL6290809 | 0.83 | L3MBTL1 (0.57) | MMP8MMP12MMP13L3MBTL1ALDH1A1 | |
| SCHEMBL11226820 | 0.79 | ACE (0.58) | MMP8MMP12MMP13ACEACE2 | |
| SCHEMBL11219531 | 0.79 | MMP8 (0.45) | MMP8MMP12MMP13ACEL3MBTL1 | |
| SCHEMBL11218699 | 0.79 | ACE (0.58) | MMP8MMP12MMP13ACEACE2 | |
| SCHEMBL11226816 | 0.79 | ACE (0.58) | MMP8MMP12MMP13ACEACE2 | |
| SCHEMBL11218694 | 0.79 | ACE (0.58) | MMP8MMP12MMP13ACEACE2 | |
| SCHEMBL11230999 | 0.79 | ACE (0.54) | ACEL3MBTL1CHRM2CHRM4CHRM1 | |
| SCHEMBL11155524 | 0.79 | HRH3 (0.55) | ACEACE2PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4342690-A | HHYPOTENSIVE AGE TS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342689-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342691-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4299769-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-11-10 | — | — | US | disclosed |