Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | ATP4A | P20648 | 2/20 | 0.52 |
| ▸ | ATP4B | P51164 | 2/20 | 0.52 |
| ▸ | MGMT | P16455 | 4/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | TPO | P07202 | 1/20 | 0.46 |
| ▸ | EPX | P11678 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747871 | 0.84 | L3MBTL1 (0.74) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL11225394 | 0.79 | L3MBTL1 (0.58) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL15055971 | 0.77 | TSHR (0.48) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL18080651 | 0.77 | L3MBTL1 (0.59) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL17164561 | 0.76 | L3MBTL1 (0.51) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL26971397 | 0.76 | L3MBTL1 (0.58) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL15088086 | 0.76 | L3MBTL1 (0.54) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL18748600 | 0.76 | L3MBTL1 (0.54) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL25345378 | 0.75 | MGMT (0.50) | L3MBTL1ATP4AATP4BMGMTCDK1 | |
| SCHEMBL29364376 | 0.75 | MGMT (0.50) | L3MBTL1ATP4AATP4BMGMTCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4343802-A | ADRENERGIC BLOCKING, ANTIARRYHYTHMIA, AND CARDIOTONIC AGENTS | MERCK, SHARP & DOHME (I.A.) CORP. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4193995-A | B-ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1980-03-18 | — | — | US | disclosed |
| US-4042586-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1977-08-16 | — | — | US | disclosed |
| US-3946009-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1976-03-23 | — | — | US | disclosed |