Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.49 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237388 | 0.84 | PDE3B (0.44) | PDE3BPDE3AHAVCR2LATS1LATS2 | |
| SCHEMBL11232990 | 0.81 | PDE3B (0.51) | PDE3BPDE3AHAVCR2HPGDALDH1A1 | |
| SCHEMBL11223425 | 0.75 | PDE3B (0.46) | PDE3BPDE3ALATS1LATS2HPGD | |
| SCHEMBL11232476 | 0.75 | GSK3B (0.49) | PDE3BPDE3ALATS1LATS2HPGD | |
| SCHEMBL11235524 | 0.74 | KDM4E (0.56) | PDE3BPDE3AHPGDALDH1A1MAPK1 | |
| SCHEMBL11238631 | 0.72 | PDE3B (0.39) | PDE3BPDE3AHAVCR2LATS1LATS2 | |
| SCHEMBL11174688 | 0.71 | PDE3B (0.53) | PDE3BPDE3AALDH1A1MAPK11MAPK14 | |
| SCHEMBL11391437 | 0.69 | PDE3B (0.57) | PDE3BPDE3AHAVCR2HPGDROCK2 | |
| SCHEMBL11240784 | 0.68 | PDE3B (0.46) | PDE3BPDE3AHPGDALDH1A1MAPK1 | |
| SCHEMBL11174660 | 0.65 | PDE3B (0.56) | PDE3BPDE3AALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |