Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.56 |
| ▸ | CASP1 | P29466 | 8/20 | 0.56 |
| ▸ | CASP7 | P55210 | 8/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229128 | 0.85 | KDM4E (0.50) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11240415 | 0.82 | KMT2A (0.46) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11223425 | 0.81 | PDE3B (0.46) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11231889 | 0.78 | KDM4E (0.49) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11232990 | 0.76 | PDE3B (0.51) | HSD17B10PDE3BPDE3AALDH1A1HPGD | |
| SCHEMBL11225855 | 0.74 | PDE3B (0.49) | HSD17B10PDE3BPDE3AALDH1A1HPGD | |
| SCHEMBL18604300 | 0.72 | PDE3B (0.43) | KDM4EPDE3BPDE3AALDH1A1HPGD | |
| SCHEMBL11233210 | 0.69 | MEN1 (0.43) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11235962 | 0.68 | PDE3B (0.42) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11238184 | 0.68 | MAPK10 (0.43) | KDM4ECASP1CASP7HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |
| EP-0058505-A1 | Preparation of esters containing an alpha-cyano group in the alcohol portion of the esters | FMC Corporation (US) | 1982-08-25 | — | — | EP | disclosed |