Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245015 | 0.85 | PDE3B (0.39) | PDE3BPDE3AMAPK1MAP4K1AKT1 | |
| SCHEMBL11367530 | 0.83 | PDE3B (0.40) | PDE3BPDE3AMAPK1FYNJAK2 | |
| SCHEMBL11237388 | 0.83 | PDE3B (0.44) | PDE3BPDE3AMAPK1KDM4EALDH1A1 | |
| SCHEMBL11232990 | 0.83 | PDE3B (0.51) | PDE3BPDE3AMAPK1ALDH1A1HPGD | |
| SCHEMBL11238864 | 0.82 | AAK1 (0.36) | PDE3BPDE3AMAPK1MAP4K1AKT1 | |
| SCHEMBL11244896 | 0.77 | GSK3B (0.49) | MAPK1AKT1ROCK2ROCK1FYN | |
| SCHEMBL11225055 | 0.76 | DYRK1A (0.43) | MAPK1KDM4EALDH1A1LMNAGAA | |
| SCHEMBL11231193 | 0.75 | MAPK1 (0.39) | MAPK1AKT1AKT2KDM4EALDH1A1 | |
| SCHEMBL11381149 | 0.74 | PDE3B (0.51) | PDE3BPDE3AKDM4ELMNAHPGD | |
| SCHEMBL11237181 | 0.71 | GSK3B (0.46) | MAPK1KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |