Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.37 |
| ▸ | POLB | P06746 | 6/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226041 | 1.00 | PSMB5 (0.38) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11225460 | 0.90 | MAPT (0.38) | ALDH1A1RECQLLMNASMN1; SMN2HTT | |
| SCHEMBL11229742 | 0.90 | ALDH1A1 (0.35) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11221306 | 0.86 | PYGL (0.34) | ALDH1A1POLBCYP2C9CYP2C19CYP3A4 | |
| SCHEMBL11232933 | 0.82 | PSMB5 (0.38) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11232931 | 0.82 | PSMB5 (0.38) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11633107 | 0.79 | PSMB5 (0.34) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11633110 | 0.79 | PSMB5 (0.34) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11231066 | 0.76 | PSMB5 (0.39) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11667840 | 0.75 | PSMB5 (0.67) | PSMB5ALDH1A1POLBCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317829-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-03-02 | — | — | US | disclosed |
| US-4284640-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-08-18 | — | — | US | disclosed |
| US-4277485-A | INHIBITORS OF GASTRIC ACID SECRETION | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-07-07 | — | — | US | disclosed |
| US-4220652-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-02 | — | — | US | disclosed |
| US-4153704-A | HETEROCYCLIC-ALKYL-AMINO SUBSTITUTED, ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-08 | — | — | US | disclosed |
| US-4124717-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-11-07 | — | — | US | disclosed |