SCHEMBL11227014

SCHEMBL11227014

COc1ccc(-c2nnc(C(=O)Cl)[nH]2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.44
PARP1 P09874 2/20 0.42
PLA2G2A P14555 1/20 0.42
ALOX15 P16050 1/20 0.42
PTGS2 P35354 1/20 0.42
NOX1 Q9Y5S8 1/20 0.41
KDM4E B2RXH2 5/20 0.41
ALDH1A1 P00352 4/20 0.41
GAA P10253 3/20 0.41
HPGD P15428 2/20 0.41
GFER P55789 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
GLA P06280 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11238251 0.78 NPC1 (0.49) PARP1ALOX15MEN1CYP1A2MAPT
SCHEMBL24317554 0.77 KDM4E (0.52) ATMPARP1NOX1KDM4EALDH1A1
SCHEMBL418165 0.73 KDM4E (0.51) ATMPARP1NOX1KDM4EALDH1A1
SCHEMBL5636442 0.71 KDM4E (0.46) ATMPARP1NOX1KDM4EALDH1A1
SCHEMBL1691510 0.71 KDM4E (0.53) ATMNOX1KDM4EALDH1A1GAA
SCHEMBL15332136 0.71 ATM (0.46) ATMPARP1NOX1KDM4EALDH1A1
SCHEMBL10171117 0.70 ALDH1A1 (0.54) KDM4EALDH1A1HPGDMAPTKMT2A
SCHEMBL13392772 0.70 HTT (0.54) KDM4EALDH1A1HPGDMAPTKMT2A
SCHEMBL21763932 0.70 TDP1 (0.46) ALDH1A1HPGDMEN1CYP1A2MAPT
SCHEMBL24195595 0.69 MEN1 (0.60) ALDH1A1MEN1MAPTKMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4326065-A PLASTICS, VARNISHES, POLYESTERS EASTMAN KODAK COMPANY (US) 1982-04-20 US disclosed
US-4251433-A BENZOTRIAZOLE DERIVATIVES; FOR POLYMERS EASTMAN KODAK COMPANY (US) 1981-02-17 US disclosed
US-4236013-A ADDITIVES FOR POLYMERS EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4137235-A ULTRAVIOLET STABILIZERS IN POLYMERIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1979-01-30 US disclosed
US-4116928-A Heterocylic ester, ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed