Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11228356 | 1.00 | FFAR3 (0.33) | FFAR3CA1CA2CES2CES1 | |
| Bicarbonate SCHEMBL11228361 | 0.94 | FFAR3 (0.33) | FFAR3CA1CA2CES2CES1 | |
| Bicarbonate SCHEMBL28332006 | 0.85 | FFAR3 (0.44) | FFAR3CA1CA2CES2CES1 | |
| Sulfuric Acid SCHEMBL11417174 | 0.82 | CA1 (0.43) | CA1CA2 | |
| Sulfuric Acid SCHEMBL11686770 | 0.78 | CA1 (0.46) | CA1CA2 | |
| Hydrogen Sulfide SCHEMBL28046696 | 0.78 | — | — | |
| Hydrogen Peroxide SCHEMBL28665394 | 0.78 | — | — | |
| Sulfuric Acid SCHEMBL29074329 | 0.76 | CA5A (0.43) | CA1CA2CES2CES1 | |
| Acetic Acid SCHEMBL3455135 | 0.76 | FFAR3 (0.50) | FFAR3 | |
| Hydrogen Sulfide SCHEMBL27262392 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322214-A | USING A SULFUR OR SULFURIZED VAT DYE IN AN ALKALINE BATH CONTAINING A MERCAPTO COMPOUND AND A SULFITE SALT; LEVELING | ASAHI CHEMICAL COMPANY LIMITED (JP) | 1982-03-30 | — | — | US | disclosed |