Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Peroxide SCHEMBL28665394 | 0.92 | — | — | |
| Acetic Acid SCHEMBL3455135 | 0.89 | FFAR3 (0.50) | FFAR3HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL1904 | 0.88 | — | — | |
| SCHEMBL2058760 | 0.88 | CA5A (0.46) | FFAR3CA1CA2CA9CA5A | |
| SCHEMBL126970 | 0.88 | — | — | |
| Carbamic Acid SCHEMBL28125004 | 0.86 | ACHE (0.47) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL11228355 | 0.85 | FFAR3 (0.33) | FFAR3CA1CA2CES2CES1 | |
| Bicarbonate SCHEMBL11228356 | 0.85 | FFAR3 (0.33) | FFAR3CA1CA2CES2CES1 | |
| Bicarbonate SCHEMBL11228361 | 0.85 | FFAR3 (0.33) | FFAR3CA1CA2CES2CES1 | |
| Benzene SCHEMBL22443739 | 0.85 | PSIP1 (0.41) | FFAR3CA1CA2CA9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110437488-A | A kind of environmental protection fluorine-free foaming agent and preparation method thereof | LIANG JIAN | 2019-11-12 | — | — | CN | disclosed |