Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014494 | 1.00 | KCNN4 (0.60) | KCNN4SRCNR1H2NR1H3MEN1 | |
| SCHEMBL11329310 | 0.85 | KCNN4 (0.56) | KCNN4SRCNR1H2NR1H3MEN1 | |
| SCHEMBL4166704 | 0.85 | KCNN4 (0.60) | KCNN4SRCNR1H2NR1H3MEN1 | |
| SCHEMBL21656187 | 0.83 | KCNN4 (0.58) | KCNN4SRCNR1H2NR1H3MEN1 | |
| SCHEMBL7959301 | 0.83 | KCNN4 (0.58) | KCNN4SRCNR1H2NR1H3MEN1 | |
| SCHEMBL4012323 | 0.83 | KCNN4 (0.58) | KCNN4SRCNR1H2NR1H3MEN1 | |
| SCHEMBL10745657 | 0.83 | PIN1 (0.53) | KCNN4MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL4012727 | 0.81 | KCNN4 (0.56) | KCNN4SRCMEN1KMT2AOPRM1 | |
| SCHEMBL10881439 | 0.81 | KCNN4 (0.56) | KCNN4SRCMEN1KMT2AOPRM1 | |
| SCHEMBL28295928 | 0.81 | KCNN4 (0.51) | KCNN4SRCNR1H2NR1H3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009306-B1 | ANTI-ARTHRITIC HYDROXYACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-24 | — | — | EP | disclosed |
| US-4310544-A | Hydroxyacetic acid derivatives with anti-arthritic properties | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-01-12 | — | — | US | disclosed |
| EP-0009306-A1 | Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-04-02 | — | — | EP | disclosed |