Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11232476 | 0.85 | GSK3B (0.49) | GSK3BCYP1A2CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL11222259 | 0.82 | GSK3B (0.76) | GSK3BCYP1A2CYP3A4CYP2C9FYN | |
| SCHEMBL11238844 | 0.73 | GSK3B (0.45) | GSK3BCYP1A2CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL11233955 | 0.72 | GSK3B (0.45) | GSK3BCYP1A2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL19790564 | 0.72 | GSK3B (0.36) | GSK3BLMNAALOX15RXFP1 | |
| SCHEMBL11235819 | 0.72 | CYP2C9 (0.38) | GSK3BCYP1A2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL15081327 | 0.71 | GSK3B (0.41) | GSK3BCHEK1ALOX15 | |
| SCHEMBL11234318 | 0.71 | GSK3B (0.46) | GSK3BCYP1A2CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL11233493 | 0.71 | GSK3B (0.58) | GSK3BCYP1A2MAPK1ALDH1A1MEN1 | |
| SCHEMBL22554308 | 0.69 | GRM5 (0.47) | GSK3BCYP2C9LMNACYP2A6CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |