Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | LATS1 | O95835 | 2/20 | 0.42 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11234318 | 0.88 | GSK3B (0.46) | GSK3BLATS1LATS2NR1D1PDGFRB | |
| SCHEMBL11232476 | 0.87 | GSK3B (0.49) | GSK3BLATS1LATS2NR1D1PDGFRB | |
| SCHEMBL11231365 | 0.81 | MAPT (0.43) | GSK3BLATS1LATS2NR1D1PDGFRB | |
| SCHEMBL11225309 | 0.76 | NR1D1 (0.39) | GSK3BLATS1LATS2NR1D1PDGFRB | |
| SCHEMBL11229759 | 0.75 | GSK3B (0.46) | GSK3BLATS1LATS2NR1D1PDGFRB | |
| SCHEMBL11229327 | 0.75 | GSK3B (0.76) | GSK3BPDGFRBPDGFRAALOX15KDM4E | |
| SCHEMBL11229298 | 0.74 | LATS1 (0.40) | GSK3BLATS1LATS2NR1D1PDGFRB | |
| SCHEMBL11237364 | 0.74 | NR1D1 (0.38) | GSK3BLATS1LATS2NR1D1PDGFRB | |
| SCHEMBL11228515 | 0.73 | GSK3B (0.52) | GSK3BPDGFRBPDGFRAALOX15MEN1 | |
| SCHEMBL11234298 | 0.72 | ROCK2 (0.42) | GSK3BLATS1LATS2NR1D1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |