Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233493 | 0.81 | GSK3B (0.58) | GSK3BCYP1A2MEN1ALDH1A1KMT2A | |
| SCHEMBL11229058 | 0.78 | LATS1 (0.39) | GSK3BGBA1ALDH1A1LMNAUTS2R | |
| SCHEMBL11222259 | 0.76 | GSK3B (0.76) | GSK3BAXLCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11229759 | 0.75 | GSK3B (0.46) | GSK3BAXLCYP3A4CYP2C19CYP1A2 | |
| SCHEMBL11228515 | 0.72 | GSK3B (0.52) | GSK3BCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11233804 | 0.72 | GBA1 (0.53) | GBA1MERTKAXLTYRO3CYP3A4 | |
| SCHEMBL11172770 | 0.69 | GRM5 (0.44) | GSK3BGBA1MERTKAXLCYP3A4 | |
| Butylamine SCHEMBL11233961 | 0.68 | CYP19A1 (0.43) | CYP3A4CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL11237964 | 0.68 | GBA1 (0.48) | GBA1MERTKAXLTYRO3CYP3A4 | |
| SCHEMBL11373768 | 0.67 | ICMT (0.49) | GBA1CYP3A4CYP2D6CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |