Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131205 | 0.86 | CA2 (0.55) | CA2HTTFFAR1CA1MAPT | |
| SCHEMBL440779 | 0.86 | CA2 (0.55) | CA2HTTFFAR1CA1MAPT | |
| SCHEMBL441033 | 0.79 | CA2 (0.59) | CA2FFAR1CA1ADRA1ADRD3 | |
| SCHEMBL11026135 | 0.79 | CA2 (0.55) | CA2FFAR1CA1PRKAB2PRKAG1 | |
| SCHEMBL11222021 | 0.77 | CA2 (0.54) | CA2HTTFFAR1PRKAB2PRKAG1 | |
| SCHEMBL11245432 | 0.76 | CA2 (0.56) | CA2HTTFFAR1MTNR1AMAPT | |
| SCHEMBL1545537 | 0.75 | HTT (0.66) | CA2HTTMTNR1AADRA1AADRA1D | |
| SCHEMBL13154391 | 0.75 | CA2 (0.51) | CA2FFAR1CA1ADRA1AADRA1D | |
| SCHEMBL11215832 | 0.75 | CA2 (0.51) | CA2FFAR1CA1MAPTPRKAB2 | |
| SCHEMBL5731186 | 0.74 | HTT (0.41) | CA2HTTMTNR1AMAPTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329348-A | ANTIDEPRESSANTS AND PSYCHOSTIMULANTS | CIBA-GEIGY CORPORATION (US) | 1982-05-11 | — | — | US | disclosed |
| EP-0004358-B1 | N-OXACYCLYLALKYL PIPERIDINES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | CIBA-GEIGY AG (CH) | 1982-01-06 | — | — | EP | disclosed |
| EP-0004358-A1 | N-oxacyclylalkyl piperidines, process for their preparation, pharmaceutical compositions containing these compounds | CIBA-GEIGY AG (CH) | 1979-10-03 | — | — | EP | disclosed |