Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 3/20 | 0.35 |
| ▸ | LDHA | P00338 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL237222 | 1.00 | — | — | |
| Urea SCHEMBL10953403 | 1.00 | CA5A (0.67) | CA5ACA5BLMNAALDH1A1TDP1 | |
| Urea SCHEMBL9242926 | 0.96 | — | — | |
| Urea SCHEMBL15517774 | 0.96 | — | — | |
| Urea SCHEMBL28964762 | 0.96 | CA5A (0.61) | CA5ACA5BLMNAALDH1A1TDP1 | |
| Urea SCHEMBL159340 | 0.96 | — | — | |
| Urea SCHEMBL9239369 | 0.96 | — | — | |
| Urea SCHEMBL11151474 | 0.96 | CA5A (0.61) | CA5ACA5BLMNAALDH1A1TDP1 | |
| Urea SCHEMBL8618275 | 0.96 | — | — | |
| Urea SCHEMBL10483813 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050120619-A1 | Emulsified fuel compositions prepared employing emulsifier derived from high polydispersity olefin polymers | KOCH FREDERICK W (US) | 2005-06-09 | — | — | US | claimed |
| US-6858046-B2 | Emulsified water-blended fuel compositions | THE LUBRIZOL CORPORATION (US) | 2005-02-22 | — | — | US | claimed |
| EP-1412624-A4 | EMULSIFIED FUEL COMPOSITIONS PREPARED EMPLOYING EMULSIFIER DERIVED FROM HIGH POLYDISPERSITY OLEFIN POLYMERS | LUBRIZOL CORP (US) | 2004-12-01 | — | — | EP | claimed |
| EP-1412624-A2 | EMULSIFIED FUEL COMPOSITIONS PREPARED EMPLOYING EMULSIFIER DERIVED FROM HIGH POLYDISPERSITY OLEFIN POLYMERS | THE LUBRIZOL CORPORATION (US) | 2004-04-28 | — | — | EP | claimed |
| US-6648929-B1 | Containing hydrocarbyl substituted succinic acid or anhydride and ammonia or an amine; stability | THE LUBRIZOL CORPORATION | 2003-11-18 | — | — | US | claimed |
| WO-2003002856-A2 | EMULSIFIED FUEL COMPOSITIONS PREPARED EMPLOYING EMULSIFIER DERIVED FROM HIGH POLYDISPERSITY OLEFIN POLYMERS | THE LUBRIZOL CORPORATION (US) | 2003-01-09 | — | — | WO | claimed |
| US-20020129541-A1 | Emulsified water-blended fuel compositions | DALY DANIEL T (US) | 2002-09-19 | — | — | US | claimed |
| EP-1123365-A1 | WATER FUEL EMULSIFIED COMPOSITIONS | The Lubrizol Corporation (US) | 2001-08-16 | — | — | EP | claimed |
| WO-2000015740-A1 | WATER FUEL EMULSIFIED COMPOSITIONS | THE LUBRIZOL CORPORATION (US) | 2000-03-23 | — | — | WO | claimed |
| CN-119677705-A | Cold combustion gas generant formulation for airbag having low burn rate slope | 奥托立夫ASP公司 | 2025-03-21 | — | — | CN | disclosed |
| EP-1490458-B1 | METHOD FOR REDUCING EMISSION OF POLLUTANTS FROM AN INTERNAL COMBUSTION ENGINE, AND FUEL EMULSION COMPRISING WATER AND A LIQUID HYDROCARBON | PIRELLI & C AMBIENTE S R L (IT) | 2015-06-10 | — | — | EP | disclosed |
| US-20130298449-A1 | METHOD FOR REDUCING EMISSION OF POLLUTANTS FROM AN INTERNAL COMBUSTION ENGINE, AND FUEL EMULSION COMPRISING WATER AND A LIQUID HYDROCARBON | CAM TECHNOLOGIE S.P.A. (IT) | 2013-11-14 | — | — | US | disclosed |
| US-8511259-B2 | Method for reducing emission of pollutants from an internal combusion engine, and fuel emulsion comprising water and a liquid hydrocarbon | CAM TECHNOLOGIE S.P.A. (IT) | 2013-08-20 | — | — | US | disclosed |
| EP-1570032-B1 | Water blended fuel composition | LUBRIZOL CORP (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2003002697-A1 | LUBRICANT INCLUDING WATER DISPERSIBLE BASE | THE LUBRIZOL CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |
| EP-1224248-A1 | PROCESS AND APPARATUS FOR MAKING AQUEOUS HYDROCARBON FUEL COMPOSITIONS, AND AQUEOUS HYDROCARBON FUEL COMPOSITIONS | The Lubrizol Corporation (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6383237-B1 | MIXTURE CONTAINING FUEL ADDITIVE AND EMULSIFIER | LUBRIZOL CORPORATION, THE | 2002-05-07 | — | — | US | disclosed |
| WO-2001004239-A1 | PROCESS AND APPARATUS FOR MAKING AQUEOUS HYDROCARBON FUEL COMPOSITIONS, AND AQUEOUS HYDROCARBON FUEL COMPOSITIONS | THE LUBRIZOL CORPORATION (US) | 2001-01-18 | — | — | WO | disclosed |
| US-5494498-A | APPLYING AQUEOUS SOLUTIONS CONTAINING UREA, AMMONIUM NITRATE AND CALCIUM NITRATE(IN CONTROLLED AMOUNTS) TO PLANTS OR SOILS TO INCREASE WATER SOLUBILITY AND CALCIUM UPTAKE | UNION OIL COMPANY OF CALIFORNIA (US) | 1996-02-27 | — | — | US | disclosed |
| US-5417737-A | Aqueous solution of urea and nitrates of ammonium and calcium | UNION OIL COMPANY OF CALIFORNIA (US) | 1995-05-23 | — | — | US | disclosed |