Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL7875816 | 0.96 | CA5A (0.57) | CA5ACA5BLMNAALDH1A1OR51E2 | |
| Urea SCHEMBL237222 | 0.96 | — | — | |
| Urea SCHEMBL10953403 | 0.96 | CA5A (0.67) | CA5ACA5BLMNAALDH1A1OR51E2 | |
| Urea SCHEMBL27597938 | 0.96 | CA5A (0.67) | CA5ACA5BLMNAALDH1A1OR51E2 | |
| Urea SCHEMBL1122882 | 0.96 | CA5A (0.67) | CA5ACA5BLMNAALDH1A1OR51E2 | |
| Urea SCHEMBL159340 | 0.92 | — | — | |
| Urea SCHEMBL9239369 | 0.92 | — | — | |
| Urea SCHEMBL9242926 | 0.92 | — | — | |
| Urea SCHEMBL8618275 | 0.92 | — | — | |
| Urea SCHEMBL11151474 | 0.92 | CA5A (0.61) | CA5ACA5BLMNAALDH1A1OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115770259-A | Application of stem cell exosome in preparation of medicine for treating uranium poisoning | 中国人民解放军陆军军医大学 | 2023-03-10 | — | — | CN | disclosed |