Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11231822 | 0.83 | GSK3A (0.37) | GSK3BAXLNR1D1PIK3CAKDM4C | |
| SCHEMBL11231889 | 0.81 | KDM4E (0.49) | GSK3BAXLPIK3CAPIK3CGKDM5A | |
| SCHEMBL11229759 | 0.81 | GSK3B (0.46) | GSK3BAXLCHEK1PDE3BPDE3A | |
| SCHEMBL11229725 | 0.79 | NR1D1 (0.37) | GSK3BAXLCHEK1PDE3BPDE3A | |
| SCHEMBL11236571 | 0.79 | NR1D1 (0.33) | GSK3BAXLCHEK1PDE3BPDE3A | |
| SCHEMBL11240332 | 0.77 | NR1D1 (0.37) | GSK3BAXLNR1D1PIK3CAKDM4C | |
| SCHEMBL11229327 | 0.75 | GSK3B (0.76) | GSK3BCHEK1PDE3BPDE3ANTRK1 | |
| SCHEMBL11232476 | 0.73 | GSK3B (0.49) | GSK3BAXLCHEK1PDE3BPDE3A | |
| SCHEMBL11234318 | 0.70 | GSK3B (0.46) | GSK3BAXLCHEK1PDE3BPDE3A | |
| SCHEMBL11238844 | 0.69 | GSK3B (0.45) | GSK3BAXLCHEK1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |