Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11789706 | 0.89 | LIMK1 (0.57) | LIMK1MAPTPOLBPDK1MKNK1 | |
| SCHEMBL11795888 | 0.89 | LIMK1 (0.52) | LIMK1MAPTPOLBPDK1MKNK1 | |
| SCHEMBL11246538 | 0.86 | LIMK1 (0.55) | LIMK1MAPTPDK1MKNK1P2RX3 | |
| SCHEMBL11786639 | 0.84 | MAPT (0.38) | LIMK1MAPTPOLBPDK1P2RX3 | |
| SCHEMBL4905684 | 0.82 | LIMK1 (0.52) | LIMK1MAPTPOLBPDK1MKNK1 | |
| SCHEMBL4904247 | 0.80 | ALDH1A1 (0.43) | LIMK1MAPTPOLBPDK1MKNK1 | |
| SCHEMBL4905260 | 0.80 | PDK1 (0.42) | LIMK1MAPTPOLBPDK1MKNK1 | |
| SCHEMBL11810317 | 0.78 | LIMK1 (0.44) | LIMK1MAPTPOLBPDK1MKNK1 | |
| SCHEMBL4895798 | 0.77 | ALDH1A1 (0.40) | LIMK1MAPTPOLBPDK1MKNK1 | |
| SCHEMBL4904164 | 0.76 | PDK1 (0.46) | LIMK1MAPTPDK1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |