Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 4/20 | 0.53 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16249736 | 0.91 | GABBR2 (0.61) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL6379988 | 0.88 | FFAR1 (0.57) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL13564512 | 0.88 | FFAR1 (0.57) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL28801346 | 0.88 | GABBR2 (0.72) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL1647112 | 0.86 | GABBR2 (0.42) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL11331773 | 0.86 | KDM4E (0.49) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL3665382 | 0.85 | FOLH1 (0.47) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL3879432 | 0.85 | ESR1 (0.59) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL3872457 | 0.85 | ESR1 (0.59) | GABBR2GABBR1LMNACYP2C9MEN1 | |
| SCHEMBL3724690 | 0.85 | ESR1 (0.59) | GABBR2GABBR1LMNACYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243608-A | 3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs | E. R. SQUIBB & SONS, INC. (US) | 1981-01-06 | — | — | US | claimed |
| US-12551490-B2 | Heterocyclic modulators of lipid synthesis | SAGIMET BIOSCIENCES INC. (US) | 2026-02-17 | — | — | US | disclosed |
| US-20240400552-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | SAGIMET BIOSCIENCES INC. | 2024-12-05 | — | — | US | disclosed |
| CN-118252986-A | Method for preparing anticoagulation coating on surface of substrate and blood contact medical device | 上海发微医用材料有限公司 | 2024-06-28 | — | — | CN | disclosed |
| US-20230405016-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | SAGIMET BIOSCIENCES INC. | 2023-12-21 | — | — | US | disclosed |
| CN-116139138-A | Heterocyclic modulators of lipid synthesis | 3-V生物科学股份有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-11622968-B2 | Heterocyclic modulators of lipid synthesis | SAGIMET BIOSCIENCES INC. (US) | 2023-04-11 | — | — | US | disclosed |
| CN-110177551-B | Heterocyclic modulators of lipid synthesis | 3-V生物科学股份有限公司 | 2023-02-17 | — | — | CN | disclosed |
| US-20220340556-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | SAGIMET BIOSCIENCES INC. | 2022-10-27 | — | — | US | disclosed |
| US-20220296605-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | SAGIMET BIOSCIENCES INC. | 2022-09-22 | — | — | US | disclosed |
| US-4345096-A | 3-/P-OXYPHENYLALKYL/GLUTARIC ACID | E. R. SQUIBB & SONS, INC. (US) | 1982-08-17 | — | — | US | disclosed |
| EP-0005834-B1 | VITAMIN B-12 DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN RADIOIMMUNOASSAYS | E.R. Squibb & Sons, Inc. (US) | 1981-10-14 | — | — | EP | disclosed |
| US-4248783-A | Steroids having a 3-(4-hydroxyphenyl)pentanedioic acid monohydrazide substituent | E. R. SQUIBB & SONS, INC. (US) | 1981-02-03 | — | — | US | disclosed |
| US-4243608-A | 3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs | E. R. SQUIBB & SONS, INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4243608-A | 3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs | E. R. SQUIBB & SONS, INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4230621-A | TRACERS, HYDROXYPHENYLGLUTARIC ACID DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1980-10-28 | — | — | US | disclosed |
| US-4221725-A | CHEMICAL INTERMEDIATE | E. R. SQUIBB & SONS, INC. (US) | 1980-09-09 | — | — | US | disclosed |
| US-4209614-A | Vitamin B12 derivative suitable for radiolabeling | E. R. SQUIBB & SONS, INC. (US) | 1980-06-24 | — | — | US | disclosed |
| EP-0005834-A1 | Vitamin B-12 derivatives, process for their preparation and their use in radioimmunoassays | E.R. Squibb & Sons, Inc. (US) | 1979-12-12 | — | — | EP | disclosed |
| US-3996291-A | Process for the production of 4-hydroxy-3,5-dibromobenzaldehyde | CIBA-GEIGY CORPORATION (US) | 1976-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340556-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | FASN, FADS1, FADS2 | GABBR2 4358/4885GABBR1 4503/4885LMNA 3576/4885 |
| US-20230405016-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | FASN, FADS1, FADS2 | GABBR2 4398/4885GABBR1 4500/4885LMNA 3910/4885 |
| US-20240400552-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | FASN, FADS1, FADS2 | GABBR2 4358/4885GABBR1 4503/4885LMNA 3576/4885 |
| US-20220296605-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | FASN, FADS1, SCD | GABBR2 4328/4885GABBR1 4441/4885LMNA 3803/4885 |
| US-12551490-B2 | Heterocyclic modulators of lipid synthesis | FASN, FADS1, FADS2 | GABBR2 3907/4885GABBR1 4202/4885LMNA 2876/4885 |
| US-11622968-B2 | Heterocyclic modulators of lipid synthesis | FASN, FADS1, SCD | GABBR2 4328/4885GABBR1 4441/4885LMNA 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.