Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236909 | 0.88 | L3MBTL1 (0.50) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| SCHEMBL11242928 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| SCHEMBL11237145 | 0.85 | NPC1 (0.47) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| SCHEMBL11242199 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| Methane SCHEMBL11228447 | 0.84 | NPC1 (0.46) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| Methane SCHEMBL11238637 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| SCHEMBL11237200 | 0.83 | ALDH1A1 (0.46) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| SCHEMBL11248260 | 0.83 | NPC1 (0.46) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| Butane SCHEMBL11229487 | 0.83 | NPC1 (0.46) | SMN1; SMN2NPC1PKMNFKB1RAB9A | |
| SCHEMBL11249067 | 0.82 | L3MBTL1 (0.46) | SMN1; SMN2NPC1PKMNFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |