Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.62 |
| ▸ | AR | P10275 | 4/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11811105 | 0.94 | PGR (0.60) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11811111 | 0.94 | PGR (0.60) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11236533 | 0.93 | PGR (0.64) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11127297 | 0.92 | PGR (0.70) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11246599 | 0.92 | PGR (0.70) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11238292 | 0.92 | PGR (0.60) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11246597 | 0.92 | PGR (0.70) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL10715139 | 0.91 | PGR (0.63) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11310688 | 0.91 | PGR (0.59) | PGRARABCB11NR3C1CYP3A4 | |
| SCHEMBL11237068 | 0.89 | ABCB11 (0.67) | PGRARABCB11NR3C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4310466-A | ANTIINFLAMMATORY STEROIDS | SYNTEX (U.S.A.) INC. (US) | 1982-01-12 | — | — | US | disclosed |
| US-4263289-A | ANTIINFLAMMATORY STEROIDS | SYNTEX (U.S.A.) INC. (US) | 1981-04-21 | — | — | US | disclosed |