SCHEMBL11230604

SCHEMBL11230604

CC(C)COc1c(N)cc(C(F)(F)F)cc1N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
GAA P10253 1/20 0.39
SCN9A Q15858 4/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
MAPT P10636 2/20 0.38
LMNA P02545 1/20 0.38
ATM Q13315 1/20 0.38
TACR1 P25103 2/20 0.37
PTPN5 P54829 2/20 0.36
IDO1 P14902 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.35
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35
THRB P10828 1/20 0.35
G6PD P11413 1/20 0.35
ALOX15 P16050 1/20 0.35
CASP1 P29466 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15061224 0.81 SCN4A (0.42) SCN9AMAPTLMNATACR1HTR2A
SCHEMBL1814147 0.79 L3MBTL1 (0.55) ALDH1A1L3MBTL1MAPTLMNAATM
SCHEMBL10352017 0.78 L3MBTL1 (0.55) ALDH1A1GAAL3MBTL1MAPTLMNA
SCHEMBL11436289 0.76 MAPT (0.42) ALDH1A1GAAL3MBTL1MAPTLMNA
SCHEMBL13155574 0.76 SCN9A (0.54) SCN9ATACR1IDO1
SCHEMBL11438172 0.76 PTPN5 (0.39) ALDH1A1GAAL3MBTL1MAPTLMNA
SCHEMBL11435743 0.75 L3MBTL1 (0.44) ALDH1A1L3MBTL1MAPTLMNAATM
SCHEMBL16357062 0.74 PTPN5 (0.38) ALDH1A1L3MBTL1MAPTLMNAATM
Hydrochloric Acid SCHEMBL9723369 0.74 KDM4E (0.39) ALDH1A1L3MBTL1MAPTLMNAATM
SCHEMBL11439374 0.74 MAPT (0.40) ALDH1A1L3MBTL1MAPTLMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4327204-A Process for producing polyurethane elastomer by mixing a hardener composition with an isocyanate composition IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1982-04-27 US disclosed
US-4195037-A 4-Alkoxy-3,5-diamino-α,α,α-trifluoromethyl-benzene and manufacture thereof and hardener for polyurethane elastomer thereof IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1980-03-25 US disclosed