Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674913 | 0.94 | HTT (0.71) | HTTNPC1RAB9AFFAR1PLA2G2A | |
| SCHEMBL7809188 | 0.88 | HTT (0.66) | HTTNPC1RAB9AFFAR1PLA2G2A | |
| SCHEMBL27954307 | 0.82 | HTT (0.58) | HTTRAB9AFFAR1PLA2G2APLA2G5 | |
| SCHEMBL27954310 | 0.82 | HTT (0.58) | HTTRAB9AFFAR1PLA2G2APLA2G5 | |
| SCHEMBL27944650 | 0.82 | HTT (0.58) | HTTRAB9AFFAR1PLA2G2APLA2G5 | |
| SCHEMBL9768518 | 0.82 | HTT (0.58) | HTTRAB9AFFAR1PLA2G2APLA2G5 | |
| SCHEMBL8085885 | 0.82 | HTT (0.58) | HTTRAB9AFFAR1PLA2G2APLA2G5 | |
| SCHEMBL27954283 | 0.82 | HTT (0.58) | HTTRAB9AFFAR1PLA2G2APLA2G5 | |
| SCHEMBL10596742 | 0.82 | HTT (0.58) | HTTRAB9AFFAR1PLA2G2APLA2G5 | |
| SCHEMBL3659193 | 0.80 | HTT (0.97) | HTTFFAR1PLA2G2APLA2G5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4343886-A | Method for stabilizing dye images in color photographic sensitive materials using a ligand as a dye image stabilizer precursor in combination with metal ions | FUJI PHOTO FILM CO., LTD. (JP) | 1982-08-10 | — | — | US | disclosed |